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Description for Protein AGL

amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
6 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 8)
Summary:
This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.4.1.25; 3.2.1.33
KEGG - Orthology:
K00705
K01196
KEGG - Pathway(s):
hsa00500; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III); GDE; Amylo-1,6-glucosidase, 4-alpha-glucanotransferase glycogen debranching enzyme Amylo-1,6-glucosidase,4-alpha-glucanotransferase (glycogen debranching enzyme); 4-alpha-glucanotransferase; Amylo-alpha-1,6-glucosidase; EC 3.2.1.33; Amylo-1,6-glucosidase; Dextrin 6-alpha-D-glucosidase; EC 2.4.1.25; Oligo-1,4-1,4-glucantransferase; Amylo-1,6-glucosidase 4-alpha-glucanotransferase isoform 2; Amylo-1,6-glucosidase 4-alpha-glucanotransferase isoform 3; Amylo-1,6-glucosidase, 4-alpha-glucanotransferase isoform 1; Amylo-1,6-glucosidase, 4-alpha-glucanotransferase 4-alphisoform 1; Amylo-1,6-glucosidase 4-alpha-glucanotransferase isoform 1
Approved Symbol:
AGL
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 10
Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01984 Entrez Gene ID: 178 OMIM ID: 610860 Swissprot Accession: P35573;