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Description for Protein DYNC1H1

dynein, cytoplasmic 1, heavy chain 1
16 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; platelet: 2)
Summary:
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • AAA: ATPases associated with a variety of cellular activities
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10413
    KEGG - Pathway(s):
    hsa04962
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Dynein cytoplasmic like; DHC1; DHC1a; DNCHC1; Dynein cytoplasmic heavy chain 1; DNCL
    Approved Symbol:
    DYNC1H1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 35
    Human (de-) phosphorylation sites: 35; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02524 Entrez Gene ID: 1778 OMIM ID: 600112 Swissprot Accession: Q14204;