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Description for Protein ACAN

aggrecan
18 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LINK: Link (Hyaluronan-binding)
  • EGF: Epidermal growth factor-like domain.
  • LECTIN_C: C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
  • SUSHI: Sushi domain (SCR repeat)
  • IG: Immunoglobulin
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06792
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Aggrecan 1 isoform 1 precursor; Aggrecan 1 isoform 2 precursor; Chondroitin sulfate proteoglycan core protein 1; CSPG1; CSPCP; Cartilage specific proteoglycan core protein 1; Aggrecan core protein; PG-M
    Approved Symbol:
    ACAN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • GM6001(db)

    Associated Genetic Diseases:

  • Spondyloepiphyseal dysplasia, Kimberley type(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01123 Entrez Gene ID: 176 OMIM ID: 155760 Swissprot Accession: P16112;