Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein DNM1

dynamin 1
48 total interacting proteins; 31 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/1)
(membrane: 1; microparticles: 1; phosphoproteome: 1; platelet: 7; undefined: 1)
Summary:
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
  • DYNC: Dynamin, GTPase
  • GED: Dynamin GTPase effector domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.5.5
    KEGG - Orthology:
    K01528
    KEGG - Pathway(s):
    hsa04144; hsa04666; hsa05100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DNM; Dynamin 1 isoform 2; Dynamin 1 isoform 1
    Approved Symbol:
    DNM1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; Platelet phosphorylation sites: 3
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03851 Entrez Gene ID: 1759 OMIM ID: 602377 Swissprot Accession: Q05193;