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Description for Protein DMBT1

deleted in malignant brain tumors 1
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SR: Scavenger receptor Cys-rich
  • CUB: Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
  • ZP: Zona pellucida (ZP) domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13912
    KEGG - Pathway(s):
    hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Deleted in malignant brain tumors 1; Surfactant, pulmonary associated protein D binding protein; Glycoprotein 340; Deleted in malignant brain tumors 1 isoform a precursor; Deleted in malignant brain tumors 1 isoform c precursor; Deleted in malignant brain tumors 1 isoform b precursor
    Approved Symbol:
    DMBT1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Glioblastoma multiforme, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03575 Entrez Gene ID: 1755 OMIM ID: 601969 Swissprot Accession: Q9UGM3;