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Description for Protein DLG3

discs, large homolog 3 (Drosophila)
53 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 4)
Summary:
This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12075
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Neuroendocrine DLG; NE-DLG; Presynaptic protein SAP102; SAP102; KIAA1232; MRX; NEDLG; Discs, large homolog 3; Synapse-associated protein 102 isoform b; XLMR; RP11-291O7.3; MRX90; bA291O7.3
    Approved Symbol:
    DLG3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Mental retardation, X-linked 90(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02177 Entrez Gene ID: 1741 OMIM ID: 300189 Swissprot Accession: Q92796; Q5JUW6; B4E0H1;