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Description for Protein NQO1

NAD(P)H dehydrogenase, quinone 1
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.6.5.2
KEGG - Orthology:
K00355
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
DHQU; NAD(P)H:Quinone acceptor oxidoreductase type 1; NAD(P)H:quinone oxireductase; Diaphorase (NADH/NADPH); Diaphorase (NADH/NADPH) (cytochrome b-5 reductase); Dioxin-inducible 1; EC 1.6.5.2; NAD(P)H menadione oxidoreductase 1, dioxin-inducible isoform c; NAD(P)H menadione oxidoreductase 1, dioxin-inducible isoform a; NAD(P)H menadione oxidoreductase 1, dioxin-inducible isoform b; Quinone reductase 1; QR1; DT diaphorase; DTD; Azoreductase; Phylloquinone reductase; Menadione reductase; NAD(P)H menadione oxidoreductase 1, dioxin inducible 1; NMOR1; Diaphorase 4; DIA4
Approved Symbol:
NQO1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2,5-Diaziridin-1-Yl-3-(Hydroxymethyl)-6-Methylcyclohexa-2,5-Diene-1,4-Dione(db);
  • 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE(db);
  • 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol(db);
  • 5-Methoxy-1,2-Dimethyl-3-(4-Nitrophenoxymethyl)Indole-4,7-Dione(db);
  • 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione(db);
  • Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone](db);
  • Cibacron Blue(db);
  • Dicumarol(db);
  • Duroquinone(db);
  • Flavin-Adenine Dinucleotide(db);
  • Menadione(db)

    Associated Genetic Diseases:

  • Benzene toxicity, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00518 Entrez Gene ID: 1728 OMIM ID: 125860 Swissprot Accession: P15559; B7ZAD1;