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Description for Protein DHODH

dihydroorotate dehydrogenase
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.3.5.2
    KEGG - Orthology:
    K00254
    KEGG - Pathway(s):
    hsa00240; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Human complement of URA1; Dihydroorotate dehydrogenase, mitochondrial; URA1; Dihydroorotate dehydrogenase isoform 1; Dihydroorotate dehydrogenase isoform 2; DHOdehase; Dihydroorotate oxidase; EC 1.3.3.1
    Approved Symbol:
    DHODH
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide(db);
  • (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide(db);
  • (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide(db);
  • (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide(db);
  • (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide(db);
  • 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID(db);
  • 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID(db);
  • 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone(db);
  • 3,6,9,12,15-PENTAOXATRICOSAN-1-OL(db);
  • 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID(db);
  • 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID(db);
  • 5-(AMINOCARBONYL)-1,1':4',1''-TERPHENYL-3-CARBOXYLICACID(db);
  • 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine(db);
  • 6-Fluoro-2-(2'-Fluoro-1,1'-Biphenyl-4-Yl)-3-Methylquinoline-4-Carboxylic Acid(db);
  • Acetate Ion(db);
  • Antiproliferative Agent A771726(db);
  • Atovaquone(db);
  • B-Octylglucoside(db);
  • Brequinar Analog(db);
  • Decylamine-N,N-Dimethyl-N-Oxide(db);
  • Lauryl Dimethylamine-N-Oxide(db);
  • Leflunomide(db);
  • N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine(db);
  • Orotic Acid(db);
  • Riboflavin Monophosphate(db);
  • UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00521 Entrez Gene ID: 1723 OMIM ID: 126064 Swissprot Accession: Q02127;