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Description for Protein DFFB

DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.-.-.-
KEGG - Orthology:
K02311
KEGG - Pathway(s):
hsa04210
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
DNA fragmentation factor, 40KDa, beta polypeptide; DFF2; DFF40; CPAN; Caspase activated deoxyribonuclease; Caspase activated nuclease; DNA fragmentation factor, 40 kD, beta polypeptide isoform 2; DNA fragmentation factor 40 kD beta polypeptide isoform 3; DNA fragmentation factor 40 kD beta polypeptide isoform 1
Approved Symbol:
DFFB
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03532 Entrez Gene ID: 1677 OMIM ID: 601883 Swissprot Accession: O76075; Q96P73;