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Description for Protein DDX11

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DEXDc: DEAD-like helicases superfamily
  • CC: Coiled Coil
  • HELIC: helicase superfamily c-terminal domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.1.-
    KEGG - Orthology:
    K11273
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    CHL1 related Helicase Gene 1; CHLR1; Keratinocyte growth factor regulated gene 2; KRG2; MGC9335; MGC133249; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11; Probable ATP-dependent RNA helicase DDX11; EC 3.6.1.-; DEAD/H Box 11; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 isoform 3
    Approved Symbol:
    DDX11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03095 Entrez Gene ID: 1663 OMIM ID: 601150 Swissprot Accession: Q96FC9; Q2NKM7;