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Description for Protein DDX3X

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
15 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(membrane: 1; microparticles: 1; platelet: 3)
Summary:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog. Alternative splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
  • DEXDc: DEAD-like helicases superfamily
  • HELIC: helicase superfamily c-terminal domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.1.-
    KEGG - Orthology:
    K11594
    KEGG - Pathway(s):
    hsa04622
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Dead/H Box 3, X-linked; Helicase-like protein 2; HLP2; DEAD/H box polypeptide 3; CAP-Rf; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DDX14; DBX; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3
    Approved Symbol:
    DDX3X
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 37
    Human (de-) phosphorylation sites: 37; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02154 Entrez Gene ID: 1654 OMIM ID: 300160 Swissprot Accession: O00571; A8K538;