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Description for Protein GADD45A

growth arrest and DNA-damage-inducible, alpha
24 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K04402
KEGG - Pathway(s):
hsa04010; hsa04110; hsa04115
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Growth arrest and DNA damage inducible gene GADD45 alpha; GADD45; DDIT1; DNA damage inducible gene GADD45; Growth arrest and DNA damage inducible protein GADD45 alpha
Approved Symbol:
GADD45A
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00528 Entrez Gene ID: 1647 OMIM ID: 126335 Swissprot Accession: Q5TCA8; P24522;