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Description for Protein TMPRSS6

transmembrane protease, serine 6
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CUB: Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
  • LDLA: Low-density lipoprotein receptor domain class A
  • TM: Transmembrane domain
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.-
    KEGG - Orthology:
    K09637
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Matriptase 2; Type II transmembrane serine protease 6; Membrane bound mosaic serine proteinase matriptase 2
    Approved Symbol:
    TMPRSS6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 10270 Entrez Gene ID: 164656 OMIM ID: 609862 Swissprot Accession: Q8IU80;