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Description for Protein DDC

dopa decarboxylase (aromatic L-amino acid decarboxylase)
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.1.1.28
KEGG - Orthology:
K01593
KEGG - Pathway(s):
hsa00340; hsa00350; hsa00360; hsa00380; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Aromatic-L-amino-acid decarboxylase; AADC; EC 4.1.1.28
Approved Symbol:
DDC
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Carbidopa(db);
  • L-Tryptophan(db);
  • Pyridoxal Phosphate(db)

    Associated Genetic Diseases:

  • Aromatic l-amino acid decarboxylase deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00145 Entrez Gene ID: 1644 OMIM ID: 107930 Swissprot Accession: P20711; Q53Y41;