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Description for Protein AP1G1

adaptor-related protein complex 1, gamma 1 subunit
24 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 6)
Summary:
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K12391
KEGG - Pathway(s):
hsa04142
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Adaptin gamma; ADTG; Clathrin associated/assembly/adaptor protein, large gamma 1; CLAPG1; Golgi adaptor HA1/AP1 adaptin gamma subunit; MGC18255; Clathrin assembly protein complex 1 gamma large chain; Adaptor-related protein complex 1, gamma 1 subunit isoform a; Adaptor-related protein complex 1, gamma 1 subunit isoform b
Approved Symbol:
AP1G1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04637 Entrez Gene ID: 164 OMIM ID: 603533 Swissprot Accession: O43747; Q8IY97;