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Description for Protein IL28RA

interleukin 28 receptor, alpha (interferon, lambda receptor)
4 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • FN3: Fibronectin type 3 domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05140
    KEGG - Pathway(s):
    hsa04060; hsa04630
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    IFNLR1; Interferon lambda receptor 1; Interleukin 28 receptor A; LICR2; CRF2/12; IFNLR; Interleukin 28 receptor, alpha interferon, lambda receptor; Class II cytokine receptor CRF2/12; Interleukin or cytokine receptor 2; IL-28R-alpha; IL-28RA; Cytokine receptor family 2 member 12; Cytokine receptor class II member 12; CRF2-12; IFN lambda R1; Likely interleukin or cytokine receptor 2; Interleukin 28 receptor alpha isoform 2; Interleukin 28 receptor alpha isoform 3
    Approved Symbol:
    IL28RA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 09589 Entrez Gene ID: 163702 OMIM ID: 607404 Swissprot Accession: Q8IU57; Q8IV66; Q5VTX7;