Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein ACE

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.15.1
    KEGG - Orthology:
    K01283
    KEGG - Pathway(s):
    hsa04614; hsa05142; hsa05410
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ACE1; Dipeptidyl carboxypeptidase 1; DCP1; Kininase II; ACE-T; DCP; CD143; MGC26566; Peptidase P; CD143 antigen; Testicular ECA; Carboxycathepsin; Peptidyl-dipeptidase A; EC 3.4.15.1; Angiotensin converting enzyme, testis specific isoform; Angiotensin converting enzyme, somatic isoform
    Approved Symbol:
    ACE
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid(db);
  • 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose(db);
  • Acetate Ion(db);
  • Benazepril(db);
  • Candoxatril(db);
  • Captopril(db);
  • Cilazapril(db);
  • Enalapril(db);
  • Fosinopril(db);
  • Lisinopril(db);
  • Moexipril(db);
  • Perindopril(db);
  • Quinapril(db);
  • Ramipril(db);
  • Rescinnamine(db);
  • Spirapril(db);
  • Trandolapril(db)

    Associated Genetic Diseases:

  • Angiotensin I-converting enzyme insertion/deletion polymorphism(Pd);
  • Angiotensin I-converting enzyme, benign serum increase(Pd);
  • Renal tubular dysgenesis(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 1
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00108 Entrez Gene ID: 1636 OMIM ID: 106180 Swissprot Accession: P12821;