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Description for Protein DCN

decorin
28 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LRR: Leucine-rich repeats, outliers
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04660
    KEGG - Pathway(s):
    hsa04350
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Decorin isoform a preproprotein; Decorin isoform b precursor; Decorin isoform c precursor; Decorin isoform d precursor; Decorin isoform e precursor; Proteoglycan II; PG II; PG40; Bone proteoglycan II; Dermatan sulphate proteoglycans II; Proteoglycan core protein; PGS2; DSPG2; SLRR1B; Small leucine rich protein 1B
    Approved Symbol:
    DCN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Tris(Hydroxymethyl)Aminomethane(db)

    Associated Genetic Diseases:

  • Corneal dystrophy, congenital stromal(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00501 Entrez Gene ID: 1634 OMIM ID: 125255 Swissprot Accession: Q6FH10; P07585;