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Description for Protein DBI

diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08762
    KEGG - Pathway(s):
    hsa03320
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ACBP; Acyl-CoA-binding protein; Endozepine; EP; Cholecystokinin-releasing peptide, trypsin-sensitive; GABA receptor modulator; Acyl-Coenzyme A binding domain containing 1; ACBD1; Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein); CCK-RP; MGC70414; Acyl coenzyme A binding protein; Diazepam binding inhibitor, splice form 1c; DBI; Diazepam binding inhibitor isoform 2; Diazepam binding inhibitor isoform 3
    Approved Symbol:
    DBI
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Coenzyme A(db);
  • Hexadecanal(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08832 Entrez Gene ID: 1622 OMIM ID: 125950 Swissprot Accession: P07108; B8ZWD2;