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Description for Protein AP1B1

adaptor-related protein complex 1, beta 1 subunit
27 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/1)
(membrane: 2; microparticles: 1; platelet: 14; secretome: 2)
Summary:
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K12392
KEGG - Pathway(s):
hsa04142
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Adaptin, beta prime; BAM22; Adaptor related protein complex 1, beta 1 subunit; Golgi adaptor HA1/AP1 adaptin beta subunit; AP105A; CLAPB2; Beta-adaptin 1; Beta-prime-adaptin; Adaptor protein complex AP-1 beta 1 subunit; Clathrin assembly protein complex 1 beta large chain; Plasma membrane adaptor HA2/AP2 adaptor beta subunit; Adaptor-related protein complex 1 beta 1 subunit isoform a; Adaptor-related protein complex 1 beta 1 subunit isoform b
Approved Symbol:
AP1B1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02541 Entrez Gene ID: 162 OMIM ID: 600157 Swissprot Accession: Q86X54; Q10567;