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Description for Protein DAPK1

death-associated protein kinase 1
21 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • ANK: ankyrin repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K08803
    KEGG - Pathway(s):
    hsa05200; hsa05219
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DAPK; DAP kinase 1
    Approved Symbol:
    DAPK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 7
    Human phosphorylation targets: 7; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine(db);
  • 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE(db);
  • Phosphoaminophosphonic Acid-Adenylate Ester(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02902 Entrez Gene ID: 1612 OMIM ID: 600831 Swissprot Accession: Q59H88; P53355;