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Description for Protein DAO

D-amino-acid oxidase
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.4.3.3
    KEGG - Orthology:
    K00273
    KEGG - Pathway(s):
    hsa00260; hsa00330; hsa00472; hsa01100; hsa04146
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DAAO; OXDA; DAMOX; MGC35381; EC 1.4.3.3
    Approved Symbol:
    DAO
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID(db);
  • 2-Aminobenzoic Acid(db);
  • 3,4-Dihydro-2h-Pyrrolium-5-Carboxylate(db);
  • Benzoic Acid(db);
  • D-Tryptophan(db);
  • Flavin-Adenine Dinucleotide(db);
  • Flavin-Adenine Dinucleotide-N5-Isobutyl Ketone(db);
  • Imino-Tryptophan(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15917 Entrez Gene ID: 1610 OMIM ID: 124050 Swissprot Accession: P14920;