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Description for Protein DGKH

diacylglycerol kinase, eta
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family of proteins, specifically the type II DGK subfamily. Members of this family are involved in regulating the intracellular concentrations of diacylglycerol and phosphatidic acid. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SAM: Sterile alpha motif.
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • DAGKC: Diacylglycerol kinase catalytic domain (presumed)
  • PH: Pleckstrin homology domain.
  • DAGKa: Diacylglycerol kinase accessory domain (presumed)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.107
    KEGG - Orthology:
    K00901
    KEGG - Pathway(s):
    hsa00561; hsa00564; hsa01100; hsa04070
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Diacylglycerol kinase, eta isoform 2; Diacylglycerol kinase, eta isoform 1; Diacylglycerol kinase, eta, 130-KD; DGKeta
    Approved Symbol:
    DGKH
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07237 Entrez Gene ID: 160851 OMIM ID: 604071 Swissprot Accession: Q86XP1;