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Description for Protein DGKB

diacylglycerol kinase, beta 90kDa
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • EF: EF-hand, calcium binding motif
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • DAGKC: Diacylglycerol kinase catalytic domain (presumed)
  • DAGKa: Diacylglycerol kinase accessory domain (presumed)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.107
    KEGG - Orthology:
    K00901
    KEGG - Pathway(s):
    hsa00561; hsa00564; hsa01100; hsa04070
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Diacylglycerol kinase, beta isoform 2; Diacylglycerol kinase, beta isoform 1; DAGK2; DGK; DGK beta; DGK 90KD; Diglyceride kinase; DAG kinase beta
    Approved Symbol:
    DGKB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06819 Entrez Gene ID: 1607 OMIM ID: 604070 Swissprot Accession: Q9Y6T7;