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Description for Protein DGKA

diacylglycerol kinase, alpha 80kDa
5 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 7)
Summary:
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • EF: EF-hand, calcium binding motif
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • DAGKC: Diacylglycerol kinase catalytic domain (presumed)
  • DAGKa: Diacylglycerol kinase accessory domain (presumed)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.107
    KEGG - Orthology:
    K00901
    KEGG - Pathway(s):
    hsa00561; hsa00564; hsa01100; hsa04070
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DAGK; Diacylglycerol kinase, Alpha, 80-KD; DAGK, 80 KD; DGK alpha; DAGK1; DAG kinase alpha; 80 kDa diacylglycerol kinase; Diglyceride kinase; ATP:1,2 diacylglycerol 3 phosphotransferase; Hypothetical protein MGC12821; Hypothetical protein MGC42356
    Approved Symbol:
    DGKA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Vitamin E(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00517 Entrez Gene ID: 1606 OMIM ID: 125855 Swissprot Accession: P23743;