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Description for Protein DAD1

defender against cell death 1
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 1/2)
(membrane: 1; platelet: 1; undefined: 1)
Summary:
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12668
    KEGG - Pathway(s):
    hsa00510; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    -
    Approved Symbol:
    DAD1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Temperature-sensitive apoptosis, cellular(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 02589 Entrez Gene ID: 1603 OMIM ID: 600243 Swissprot Accession: P61803; Q53G02;