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Description for Protein AP2A1

adaptor-related protein complex 2, alpha 1 subunit
26 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(membrane: 2; microparticles: 1; platelet: 4)
Summary:
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11824
    KEGG - Pathway(s):
    hsa04144; hsa05016
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Adaptin alpha; Clathrin adaptor complex AP2 alpha subunit; CLAPA1; Clathrin associated/assembly/adaptor protein Large Alpha 1; ADTAA; AP2 ALPHA; 100 kDa coated vesicle protein A; Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit; Adaptor related protein complex 2 alpha 1 subunit isoform 1; Adaptor related protein complex 2 alpha 1 subunit isoform 2
    Approved Symbol:
    AP2A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03016 Entrez Gene ID: 160 OMIM ID: 601026 Swissprot Accession: O95782;