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Description for Protein CYP19A1

cytochrome P450, family 19, subfamily A, polypeptide 1
5 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.14.1
    KEGG - Orthology:
    K07434
    KEGG - Pathway(s):
    hsa00140; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cytochrome P450, family 19; Microsomal monooxygenase; Flavoprotein-linked monooxygenase; Aromatase; ARO; CYP19; Estrogen synthetase; CYPXIX; EC 1.14.14.1; ARO1; CPV1; CYAR; P-450AROM
    Approved Symbol:
    CYP19A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-ANDROSTENE-3-17-DIONE(db);
  • Aminoglutethimide(db);
  • Anastrozole(db);
  • Exemestane(db);
  • Letrozole(db);
  • Testolactone(db)

    Associated Genetic Diseases:

  • Aromatase deficiency(Pd);
  • Aromatase deficiency, placental(Pd);
  • Gynecomastia, familial, due to increased aromatase activity(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00488 Entrez Gene ID: 1588 OMIM ID: 107910 Swissprot Accession: Q8TCA4; P11511; Q05CU4;