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Description for Protein CYP11B2

cytochrome P450, family 11, subfamily B, polypeptide 2
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.14.15.4; 1.14.15.5
KEGG - Orthology:
K07433
KEGG - Pathway(s):
hsa00140; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Steroid 11 beta hydroxylase; Aldosterone synthatase; EC 1.14.15.4; EC 1.14.15.5
Approved Symbol:
CYP11B2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Aldosterone to renin ratio, increased(Pd);
  • Corticosterone methyloxidase type I deficiency(Pd);
  • Corticosterone methyloxidase type II deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00492 Entrez Gene ID: 1585 OMIM ID: 124080 Swissprot Accession: P19099;