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Description for Protein CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.14.1
    KEGG - Orthology:
    K07424
    KEGG - Pathway(s):
    hsa00140; hsa00591; hsa00830; hsa00980; hsa00982; hsa00983; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CYP3; CYP3A; P450, family 3; P450 3, steroid inducible; Glucocorticoid inducible P450; P450C3; Cytochrome P450PCN1; Nifedipine oxidase; Quinine 3 monooxygenase; CYPIIIA4; NF 25; P450 PCN1; EC 1.14.13.67
    Approved Symbol:
    CYP3A4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Heme(db)

    Associated Genetic Diseases:

  • CYP3A4 promoter polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 00484 Entrez Gene ID: 1576 OMIM ID: 124010 Swissprot Accession: P08684; Q6GRK0; P05184;