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Description for Protein CYP2E1

cytochrome P450, family 2, subfamily E, polypeptide 1
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.14.1
    KEGG - Orthology:
    K07415
    KEGG - Pathway(s):
    hsa00590; hsa00591; hsa00980; hsa00982; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CPE1; CYP2E; P450 J; P450C2E; Microsomal monooxygenase; Xenobiotic monooxygenase; Flavoprotein linked monooxygenase; Cytochrome P450 subfamily IIE ethanol inducible; Cytochrome P450 subfamily IIE ethanol inducible polypeptide 1; Ethanol inducibe P450
    Approved Symbol:
    CYP2E1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • CYP2E polymorphism c/d(Pd);
  • CYP2E polymorphism c1/c2(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 11813 Entrez Gene ID: 1571 OMIM ID: 124040 Swissprot Accession: P05181;