Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein ADRBK1

adrenergic, beta, receptor kinase 1
42 total interacting proteins; 26 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(membrane: 1; phosphoproteome: 1; platelet: 2; undefined: 1)
Summary:
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • RGS: Regulator of G protein signalling domain
  • PH: Pleckstrin homology domain.
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.15
    KEGG - Orthology:
    K00910
    KEGG - Pathway(s):
    hsa04062; hsa04144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    BARK1; BARK; BETA ARK1; Beta adrenergic receptor kinase1; GRK2; Adrenergic, beta, receptor kinase 1
    Approved Symbol:
    ADRBK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 19
    Human phosphorylation targets: 18; Predicted platelet targets: 1
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine triphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00182 Entrez Gene ID: 156 OMIM ID: 109635 Swissprot Accession: P25098;