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Description for Protein CYP2C9

cytochrome P450, family 2, subfamily C, polypeptide 9
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.14.1
    KEGG - Orthology:
    K07413
    KEGG - Pathway(s):
    hsa00590; hsa00591; hsa00830; hsa00980; hsa00982; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CYPIIC9; P450 PB-1; P450 MP-4; P-450MP; Cytochrome P450, subfamily IIC, polypeptide 10; Mephenytoin 4-hydroxylase; Microsomal monooxygenase; Xenobiotic monooxygenase; Flavoprotein-linked monooxygenase
    Approved Symbol:
    CYP2C9
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One(db);
  • Heme(db);
  • Heme C(db)

    Associated Genetic Diseases:

  • Tolbutamide poor metabolizer(Pd);
  • Warfarin sensitivity(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03084 Entrez Gene ID: 1559 OMIM ID: 601130 Swissprot Accession: P11712; Q5VX92;