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Description for Protein CYP2C19

cytochrome P450, family 2, subfamily C, polypeptide 19
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.14.1
    KEGG - Orthology:
    K07413
    KEGG - Pathway(s):
    hsa00590; hsa00591; hsa00830; hsa00980; hsa00982; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Flavoprotein linked monooxygenase; P450C2C; Mephenytoin 4` hydroxylase; EC 1.14.13.80; EC 1.14.13.48; EC 1.14.13.49
    Approved Symbol:
    CYP2C19
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Mephenytoin, poor metabolism of(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00486 Entrez Gene ID: 1557 OMIM ID: 124020 Swissprot Accession: P33261;