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Description for Protein CYP1A2

cytochrome P450, family 1, subfamily A, polypeptide 2
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.14.1
    KEGG - Orthology:
    K07409
    KEGG - Pathway(s):
    hsa00232; hsa00380; hsa00591; hsa00830; hsa00980; hsa00982; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cytochrome P450, aromatic compound inducible; Dioxin inducible P3-450; Phenacetin metabolism, defect in; Phenacetin O deethylase, deficiency of; P450 P3; P(3)450; P450 4; CP12; EC 1.14.14.1
    Approved Symbol:
    CYP1A2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00489 Entrez Gene ID: 1544 OMIM ID: 124060 Swissprot Accession: P05177;