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Description for Protein CYP1A1

cytochrome P450, family 1, subfamily A, polypeptide 1
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide

  • Gene Ontology:
    Gene Ontology Annotations

    KEGG - Enzyme ID(s):
    1.14.14.1
    KEGG - Orthology:
    K07408
    KEGG - Pathway(s):
    hsa00140; hsa00380; hsa00830; hsa00980
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cytochrome P450, aromatic compound inducible; Arylhydrocarbon hydroxylase; AHH; Flavoprotein linked monooxygenase; Cytochrome P1-450, dioxin inducible; Cytochrome P1-450, inducible by 2,3,7,8-tetrachlorodibenzo P dioxin; TCDD-inducible cytochrome P1-450; P450DX; Polycyclic aromatic compound inducible P450; P450-P1; P450 form 6; P450-C; EC 1.14.14.1
    Approved Symbol:
    CYP1A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites

    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available


    Associated Genetic Diseases:

    None Available
    Predicted Transmembrane Domains:
  • Isoform 1 : 1
  • Additional Identifiers:

    HPRD: 00148 Entrez Gene ID: 1543 OMIM ID: 108330 Swissprot Accession: P04798A0N0X8