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Description for Protein CYLD

cylindromatosis (turban tumor syndrome)
26 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.1.2.15
KEGG - Orthology:
K08601
KEGG - Pathway(s):
hsa04622
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
CYLD1; Ubiquitin carboxyl-terminal hydrolase CYLD isoform 2; Ubiquitin carboxyl-terminal hydrolase CYLD isoform 1
Approved Symbol:
CYLD
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 18
Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Cylindromatosis, familial(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05427 Entrez Gene ID: 1540 OMIM ID: 605018 Swissprot Accession: Q9NQC7;