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Description for Protein ADRB2

adrenergic, beta-2-, receptor, surface
34 total interacting proteins; 22 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04142
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04144; hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    B2AR; ADRB2R
    Approved Symbol:
    ADRB2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 22
    Human (de-) phosphorylation sites: 22; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol(db);
  • (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol(db);
  • Acebutolol(db);
  • Alprenolol(db);
  • Arbutamine(db);
  • Arformoterol(db);
  • Bambuterol(db);
  • Betaxolol(db);
  • Bevantolol(db);
  • Bisoprolol(db);
  • Bitolterol(db);
  • Bopindolol(db);
  • Bupranolol(db);
  • Carteolol(db);
  • Carvedilol(db);
  • Clenbuterol(db);
  • Desipramine(db);
  • Dipivefrin(db);
  • Dobutamine(db);
  • Droxidopa(db);
  • Ephedra(db);
  • Epinephrine(db);
  • Fenoterol(db);
  • Formoterol(db);
  • Isoproterenol(db);
  • Labetalol(db);
  • Levobunolol(db);
  • Metipranolol(db);
  • Metoprolol(db);
  • Nadolol(db);
  • Nebivolol(db);
  • Norepinephrine(db);
  • Orciprenaline(db);
  • Oxprenolol(db);
  • Penbutolol(db);
  • Phenoxybenzamine(db);
  • Pindolol(db);
  • Pirbuterol(db);
  • Procaterol(db);
  • Propranolol(db);
  • Pseudoephedrine(db);
  • Ritodrine(db);
  • Salbutamol(db);
  • Salmeterol(db);
  • Sotalol(db);
  • Terbutaline(db);
  • Timolol(db)

    Associated Genetic Diseases:

  • Asthma, nocturnal, susceptibility to(Pd);
  • Beta-2-adrenoreceptor agonist, reduced response to(Pd);
  • Obesity, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00187 Entrez Gene ID: 154 OMIM ID: 109690 Swissprot Accession: P07550;