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Description for Protein CYBB

cytochrome b-245, beta polypeptide
8 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08008
    KEGG - Pathway(s):
    hsa04670
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CGD; gp91 Phox; NADPH oxidase 2; NOX2; GP91 1; Cytochrome B 245 heavy chain; P22 phagocyte B cytochrome; Neutrophil cytochrome B; CGD91 PHOX; GP91 PHOX; Heme binding membrane glycoprotein; Cytochrome B(558) beta chain; Superoxide generating NADPH oxidase heavy chain subunit
    Approved Symbol:
    CYBB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Granulomatous disease, chronic, X-linked(Pd);
  • Granulomatous disease, chronic, X-linked, somatic mosaic(Pd);
  • Granulomatous disease, chronic, X-linked, variant(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 02382 Entrez Gene ID: 1536 OMIM ID: 300481 Swissprot Accession: P04839;