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Description for Protein CYBA

cytochrome b-245, alpha polypeptide
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08009
    KEGG - Pathway(s):
    hsa04670; hsa05140
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    p22-PHOX; p22 phagocyte B-cytochrome; Neutrophil cytochrome B, 22 kDa polypeptide; p22phox; Cytochrome B(558) alpha chain; Cytochrome b558 alpha subunit; Superoxide generating NADPH oxidase light chain subunit; Cytochrome b-245 light chain; Cytochrome b-245 alpha chain
    Approved Symbol:
    CYBA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Cyba polymorphism 242c-t(Pd);
  • Granulomatous disease, chronic, autosomal recessive, cytochrome B-negative(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 01989 Entrez Gene ID: 1535 OMIM ID: 608508 Swissprot Accession: P13498;