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Description for Protein DAB2IP

DAB2 interacting protein
7 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • C2: Protein kinase C conserved region 2 (CalB)
  • RASGAP: GTPase-activator protein for Ras-like GTPases
  • PH: Pleckstrin homology domain.
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    KIAA1743; AF9Q34; DIP1/2; nGAP like protein; DOC 2/DAB2 interactive protein; ASK interacting protein; AIP1; DAB2 interacting protein isoform 2; DAB2 interacting protein isoform 1
    Approved Symbol:
    DAB2IP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 41
    Human (de-) phosphorylation sites: 41; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09903 Entrez Gene ID: 153090 OMIM ID: 609205 Swissprot Accession: Q5VWQ8;