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Description for Protein ADRB1

adrenergic, beta-1-, receptor
16 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04141
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04144; hsa04540; hsa04970; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ADRB1R; B1AR
    Approved Symbol:
    ADRB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL(db);
  • 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile(db);
  • Acebutolol(db);
  • Alprenolol(db);
  • Amiodarone(db);
  • Arbutamine(db);
  • Atenolol(db);
  • Betaxolol(db);
  • Bevantolol(db);
  • Bisoprolol(db);
  • Bopindolol(db);
  • Bupranolol(db);
  • Carteolol(db);
  • Carvedilol(db);
  • Clenbuterol(db);
  • Desipramine(db);
  • Dobutamine(db);
  • Droxidopa(db);
  • Ephedra(db);
  • Epinephrine(db);
  • Esmolol(db);
  • Fenoterol(db);
  • Isoetharine(db);
  • Isoproterenol(db);
  • Labetalol(db);
  • Levobunolol(db);
  • Metipranolol(db);
  • Metoprolol(db);
  • Nadolol(db);
  • Nebivolol(db);
  • Norepinephrine(db);
  • Oxprenolol(db);
  • Penbutolol(db);
  • Phenylpropanolamine(db);
  • Pindolol(db);
  • Pirbuterol(db);
  • Practolol(db);
  • Propranolol(db);
  • Pseudoephedrine(db);
  • Salbutamol(db);
  • Sotalol(db);
  • Timolol(db)

    Associated Genetic Diseases:

  • Beta-1-adrenergic receptor polymorphism, gain-of-function(Pd);
  • Resting heart rate(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00181 Entrez Gene ID: 153 OMIM ID: 109630 Swissprot Accession: P08588;