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Description for Protein CX3CR1

chemokine (C-X3-C motif) receptor 1
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04192
    KEGG - Pathway(s):
    hsa04060; hsa04062
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Fractalkine receptor CX3CR1; G protein coupled receptor 13; G protein coupled receptor V28; V28; CMKDR1; CMKBRL1; GPRV28; GPR13; CMK-BRL1; (CCRL1)
    Approved Symbol:
    CX3CR1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Human immunodeficiency virus type 1, rapid progression to aids(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 03277 Entrez Gene ID: 1524 OMIM ID: 601470 Swissprot Accession: P49238;