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Description for Protein ADRA2C

adrenergic, alpha-2C-, receptor
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04140
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Alpha 2C adrenoceptor
    Approved Symbol:
    ADRA2C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Apomorphine(db);
  • Aripiprazole(db);
  • Bethanidine(db);
  • Brimonidine(db);
  • Bromocriptine(db);
  • Cabergoline(db);
  • Clonidine(db);
  • Clozapine(db);
  • Doxepin(db);
  • Droxidopa(db);
  • Ephedra(db);
  • Fenoldopam(db);
  • Lisuride(db);
  • Methamphetamine(db);
  • Methotrimeprazine(db);
  • Norepinephrine(db);
  • Olanzapine(db);
  • Paliperidone(db);
  • Pergolide(db);
  • Phenoxybenzamine(db);
  • Pramipexole(db);
  • Quetiapine(db);
  • Risperidone(db);
  • Ropinirole(db);
  • Tizanidine(db);
  • Xylometazoline(db);
  • Yohimbine(db);
  • Ziprasidone(db)

    Associated Genetic Diseases:

  • Congestive heart failure, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00085 Entrez Gene ID: 152 OMIM ID: 104250 Swissprot Accession: P18825; Q4W594;