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Description for Protein ADRA2B

adrenergic, alpha-2B-, receptor
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04139
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ADRA2L1; Alpha 2B adrenoceptor; Alpha 2 adrenergic receptor like 1
    Approved Symbol:
    ADRA2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Apomorphine(db);
  • Aripiprazole(db);
  • Bethanidine(db);
  • Brimonidine(db);
  • Bromocriptine(db);
  • Cabergoline(db);
  • Clonidine(db);
  • Clozapine(db);
  • Doxepin(db);
  • Droxidopa(db);
  • Ephedra(db);
  • Epinephrine(db);
  • Ergotamine(db);
  • Etomidate(db);
  • Fenoldopam(db);
  • Lisuride(db);
  • Methamphetamine(db);
  • Methotrimeprazine(db);
  • Norepinephrine(db);
  • Olanzapine(db);
  • Paliperidone(db);
  • Pergolide(db);
  • Phenoxybenzamine(db);
  • Pramipexole(db);
  • Quetiapine(db);
  • Risperidone(db);
  • Ropinirole(db);
  • Tizanidine(db);
  • Trimipramine(db);
  • Xylometazoline(db);
  • Yohimbine(db);
  • Ziprasidone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00086 Entrez Gene ID: 151 OMIM ID: 104260 Swissprot Accession: P18089; A2RUS0;