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Description for Protein CTSD

cathepsin D
18 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/2)
(membrane: 1; microparticles: 1; platelet: 2; secretome: 1; undefined: 1)
Summary:
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.23.5
    KEGG - Orthology:
    K01379
    KEGG - Pathway(s):
    hsa04142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CATD; Cathepsin D, lysosomal aspartyl protease
    Approved Symbol:
    CTSD
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1h-Benoximidazole-2-Carboxylic Acid(db);
  • 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID(db);
  • Alpha-D-Mannose(db);
  • CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE(db);
  • Insulin recombinant(db);
  • Insulin, porcine(db);
  • N-Aminoethylmorpholine(db);
  • S-Methylcysteine(db)

    Associated Genetic Diseases:

  • Ceroid lipofuscinosis, neuronal, 10(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00291 Entrez Gene ID: 1509 OMIM ID: 116840 Swissprot Accession: P07339;