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Description for Protein CTRB1

chymotrypsinogen B1
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Alpha-chymotrypsin (EC 3.4.21.1) is one of a family of serine proteases secreted into the gastrointestinal tract as the inactive precursor chymotrypsinogen. The zymogen is activated by proteolytic cleavage by trypsin (PRSS1; MIM 276000).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.1
    KEGG - Orthology:
    K01310
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    FLJ42412; MGC88037; EC 3.4.21.1; CTRB; Chymotrypsinogen B; Alpha chymotrypsinogen
    Approved Symbol:
    CTRB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S) N-ACETYL-L-ALANYL-ALPHAL-PHENYLALANYL-CHLOROETHYLKETONE(db);
  • 1,1,1-TRIFLUORO-3-((N-ACETYL)-L-LEUCYLAMIDO)-4-PHENYL-BUTAN-2-ONE(N-ACETYL-L-LEUCYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE)(db);
  • 1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE)(db);
  • 2,4-Dihydroxy-Trans Cinnamic Acid(db);
  • 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDE(db);
  • 3-(4-DIETHYLAMINO-2-HYDROXY-PHENYL)-2-METHYL-PROPIONIC ACID(db);
  • Aprotinin(db);
  • D-1-(4-CHLOROPHENYL)-2-(ACETAMIDO)ETHANE BORONIC ACID(db);
  • D-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID(db);
  • L-1-(4-CHLOROPHENYL)-2-(ACETAMIDO)ETHANE BORONIC ACID(db);
  • L-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID(db);
  • N-(1-BENZYL-3,3,3-TRIFLUORO-2,2-DIHYDROXY-PROPYL)-ACETAMIDE(db);
  • PHENYLALANYLMETHYLCHLORIDE(db);
  • Phenylethane Boronic Acid(db);
  • Phosphorylisopropane(db);
  • Trans-O-Hydroxy-Alpha-Methyl Cinnamate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00345 Entrez Gene ID: 1504 OMIM ID: 118890 Swissprot Accession: P17538;