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Description for Protein AANAT

aralkylamine N-acetyltransferase
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.3.1.87
KEGG - Orthology:
K00669
KEGG - Pathway(s):
hsa00380; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Serotonin N-acetyltransferase; SNAT; Serotonin acetylase
Approved Symbol:
AANAT
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Coa-S-Acetyl 5-Bromotryptamine(db);
  • Coa-S-Acetyl Tryptamine(db);
  • Coa-S-Trimethylene-Acetyl-Tryptamine(db)

    Associated Genetic Diseases:

  • Delayed sleep phase syndrome, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02974 Entrez Gene ID: 15 OMIM ID: 600950 Swissprot Accession: Q16613;