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Description for Protein CTNNB1

catenin (cadherin-associated protein), beta 1, 88kDa
195 total interacting proteins; 70 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene. (PubMed Links)
Domains and Motifs:
  • ARM: Armadillo/beta-catenin-like repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02105
    KEGG - Pathway(s):
    hsa04310; hsa04510; hsa04520; hsa04530; hsa04670; hsa04916; hsa05100; hsa05130; hsa05200; hsa05210; hsa05213; hsa05215; hsa05216; hsa05217; hsa05412
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Catenin, beta 1; Cadherin associated protein, beta; CTNNB
    Approved Symbol:
    CTNNB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 32
    Human (de-) phosphorylation sites: 32; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Urea(db)

    Associated Genetic Diseases:

  • Colorectal cancer(Pd);
  • Hepatoblastoma, somatic(Pd);
  • Hepatocellular carcinoma, somatic(Pd);
  • Ovarian carcinoma, endometrioid type, somatic(Pd);
  • Pilomatricoma, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00286 Entrez Gene ID: 1499 OMIM ID: 116806 Swissprot Accession: P35222;