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Description for Protein CTLA4

cytotoxic T-lymphocyte-associated protein 4
15 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • IG: Immunoglobulin
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06538
    KEGG - Pathway(s):
    hsa04514; hsa04660; hsa05320
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cytotoxic T-lymphocyte-associated protein 4 isoform a precursor; Cytotoxic T-lymphocyte-associated protein 4 isoform b precursor; Cytotoxic T lymphocyte associated 4; Cytotoxic T lymphocyte antigen 4
    Approved Symbol:
    CTLA4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-D-Mannose(db);
  • Fucose(db)

    Associated Genetic Diseases:

  • Graves disease, susceptibility to(Pd);
  • Hashimoto thyroiditis, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 00474 Entrez Gene ID: 1493 OMIM ID: 123890 Swissprot Accession: P16410; O95653;